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Ovarian Fallopian Primary Peritoneal phase 2 Accepting New Patients
A Single-Arm, Phase 2 Study of Neoadjuvant Carboplatin and Mirvetuximab Soravtansine in Subjects With FRα-Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Principal Investigator: Michelle Rowland MD PhD MPH
Clinical Research Coordinator: Lisa Gale MSN RN CCRC
Clinicaltrials.gov Identifier: NCT06890338

Lung phase 1 Accepting New Patients
A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-8520 in Subjects With Advanced KRASG12C Mutant Non-Small Cell Lung Cancer - The ONKORAS-101 Study

Principal Investigator: Jun Zhang MD PhD
Clinical Research Coordinator: Vishnu Jaisree Mohandas MBBS MPH
Clinicaltrials.gov Identifier: NCT06343402

Lung phase 1 Accepting New Patients
Study of NMS-03305293, a Non-Trapping PARP1-Specific PARP Inhibitor in Relapsed Small Cell Lung Cancer

Principal Investigator: Jun Zhang MD PhD
Clinical Research Coordinator: Vishnu Jaisree Mohandas MBBS MPH
Clinicaltrials.gov Identifier: NCT06931626

Lung phase 1 Accepting New Patients
A Phase 1b, Two-Part Study of Tolododekin Alfa (ANK-101) in Combination With an Anti-PD-1/PD-L1 Antibody in Participants With Advanced Non-Small Cell Lung Cancer

Principal Investigator: Jun Zhang MD PhD
Clinical Research Coordinator: Vishnu Jaisree Mohandas MBBS MPH
Clinicaltrials.gov Identifier: NCT07027514

Cervical phase 4 Accepting New Patients
A PROSPECTIVE LOW-INTERVENTIONAL PHASE 4 SINGLE ARM STUDY OF OCULAR ASSESSMENTS IN PATIENTS TREATED WITH TIVDAK® IN RECURRENT OR METASTATIC CERVICAL CANCER

Principal Investigator: Michelle Rowland MD PhD MPH
Clinical Research Coordinator: Lisa Gale MSN RN CCRC
Clinicaltrials.gov Identifier: NCT06952660

Lung phase 3 Accepting New Patients
A Randomized, Open-Label, Phase 3 Study of ZL-1310, a DLL3 Antibody-Drug Conjugate (ADC), Compared to Investigator's Choice Therapy in Participants With Relapsed Small Cell Lung Cancer

Principal Investigator: Jun Zhang MD PhD
Clinical Research Coordinator: Vishnu Jaisree Mohandas MBBS MPH
Clinicaltrials.gov Identifier: NCT07218146

Endometrial phase 3 Accepting New Patients
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4 Selected Advanced/Metastatic Endometrial Cancer Who Progressed On or After Platinum Based Chemotherapy and Anti-PD-1/Anti-PD-L1 Therapy (Bluestar-Endometrial01)

Principal Investigator: Michelle Rowland MD PhD MPH
Clinical Research Coordinator: Lisa Gale MSN RN CCRC
Clinicaltrials.gov Identifier: NCT07044336

Lung phase 1 Accepting New Patients
A Phase 1b Study of Gilteritinib in Participants With Locally Advanced or Metastatic NSCLC With ALK Rearrangement After Prior Treatment With an ALK Inhibitor

Principal Investigator: Jun Zhang MD PhD
Clinical Research Coordinator: Jennifer Dixon RN
Clinicaltrials.gov Identifier: NCT07140016

Ovarian Endometrial phase 1 Accepting New Patients
A Phase 1 First-in-Human Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.

Principal Investigator: Michelle Rowland MD PhD MPH
Clinical Research Coordinator: Lisa Gale MSN RN CCRC
Clinicaltrials.gov Identifier: NCT07470853

Solid Tumors phase 1 Accepting New Patients
A Phase 1b/2, Open-label, Multi-center Study of ZL-1310 in Participants With Selected Solid Tumors

Principal Investigator: Robert McWilliams, MD, PhD
Clinical Research Coordinator: Peyton Swearingen
Clinicaltrials.gov Identifier: NCT06885281

Pancreatic expanded access program Accepting New Patients
Expanded Access Program to Treat Patients With Previously Treated Metastatic Pancreatic Adenocarcinoma With Daraxonrasib

Principal Investigator: Robert McWilliams, MD, PhD
Clinical Research Coordinator: Peyton Swearingen
Clinicaltrials.gov Identifier: NCT07573215

Lung Pancreatic Colorectal phase 1 Accepting New Patients
A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-11818 in Subjects With Advanced KRAS Mutant Cancers

Principal Investigator: Jun Zhang, MD, PhD
Clinical Research Coordinator: Jennifer Dixon
Clinicaltrials.gov Identifier: NCT06917079

Lung phase 1 Accepting New Patients
A Multicenter, Open-Label, Phase 1a/b First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BG-C477 in Patients With Selected Advanced Solid Tumors

Principal Investigator: Jun Zhang, MD, PhD
Clinical Research Coordinator: Jennifer Dixon
Clinicaltrials.gov Identifier: NCT06596473

Ovarian phase 3 Accepting New Patients
A Randomised, Open-label, Phase III Study of AZD5335 Versus Mirvetuximab Soravtansine in FRα-high and AZD5335 Versus Investigator's Choice Chemotherapy in FRα-low Expressing High-grade Platinum-resistant Epithelial Ovarian Cancer Patients (TREVI-OC-01)

Principal Investigator: Michelle Rowland MD PhD MPH
Clinical Research Coordinator: Lisa Gale
Clinicaltrials.gov Identifier: NCT07218809

Liver phase 2 Accepting New Patients
A Phase 2b, Randomized, Blinded Trial Investigating the Efficacy and Safety of Visugromab in Combination With Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Participants With Unresectable or Metastatic Hepatocellular Carcinoma and Compensated Liver Function (Child-Pugh A) After Failure of First-Line Treatment That Included an Approved Anti PD-(L)1 Compound (GDFATHER HCC-01)

Principal Investigator: Robert McWilliams, MD, PhD
Clinical Research Coordinator: Peyton Swearingen, BS
Clinicaltrials.gov Identifier: NCT07219459

Ovarian Endometrial Lung phase 1 Accepting New Patients
A Phase 1 First-in-Human Study of PTK7-Directed Antibody Drug Conjugate HWK-007 in Participants With Advanced Solid Tumors

Principal Investigator: Michelle Rowland MD PhD MPH
Clinical Research Coordinator: Lisa Gale MSN RN CCRC
Clinicaltrials.gov Identifier: NCT07444814

Endometrial phase 3 Accepting New Patients
A Phase III, Randomized, Multi-site, Open-label Trial of BNT323/DB-1303 Versus Investigator's Choice of Chemotherapy in Previously Treated Patients With HER2- Expressing Recurrent Endometrial Cancer

Principal Investigator: Michelle Rowland MD PhD MPH
Clinical Research Coordinator: Lisa Gale MSN RN CCRC
Clinicaltrials.gov Identifier: NCT06340568

Ovarian phase 1 Closed to Enrollment
Study of NMS-03305293, a Non-Trapping PARP1-Specific PARP Inhibitor in Relapsed Ovarian Cancer

Principal Investigator: Michelle Rowland MD PhD MPH
Clinical Research Coordinator: Lisa Gale MSN RN CCRC
Clinicaltrials.gov Identifier: NCT06930755

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